PROGRAM OF EVENTS
Sunday, November 9, 2008
Arrival & registration
20:00Welcome dinner
Monday, November 10, 2008
7:00 - 8:30Breakfast
8:30 - 9:30

Plenary session. State of the art on copper
Magdalena Araya. Copper effects in human nutrition
Leo Klomp. Copper homeostasis disorders; a tale of dogs, mice and men .

9:30 - 10:30

Plenary session. State of the art on iron
Elizabeth Theil. Frontiers in iron nutrition and antioxidant metabolism.
Caroline C. Philpott. A cytosolic iron chaperone that delivers iron to ferritin.

10:30 -11:00Coffee break
11:00 - 12:00

Plenary session. State of the art on zinc
Michael Hambidge. Human zinc deficiency: new insights into zinc homeostasis provide a quantitative basis for prevention and treatment of a new public health challenge.
Juan Pablo Liuzzi. Zinc research: current status and future perspectives.

12:00 - 13:00

Plenary session. State of the art on Selenium
Roger Sunde. Molecular selenium nutrition – from discovery to molecular biology biomarkers for selenium status and requirements.
adim N Gladyshev. Selenoproteins and their roles in redox biology.

13:00 - 14:00Lunch
15:00 - 17:00

Symposium 1. Advances in Proteomics. Analytical, structural and functional aspects
D Behne (chair). Trace elements as binding partners of proteins.
Dirk Schaumloeffel. Detection of trace element-containing proteins.
Brian Gibney. Modern methods of analysis of Zn proteins

Symposium 2. Transition metals and oxidative stress
Hernán Speisky (chair). Cu(I)-glutathione complex: a new biological source of superoxide radicals?
Marco Tulio Nuñez. An iron-calcium connection in nmda receptor signaling and hippocampal synaptic plasticity.
Xingen Lei. Hidden roles of Se-GPX1 and Cu,Zn-SOD

Symposium 3. Advances in the use of stable isotopes for applications in humans.
Nancy Krebs (chair). Zinc homeostasis: taking current knowledge to the field
Leland V. Miller. Zinc absorption: modeling the impact of dietary factors
Lena Davidsson. Iron absorption in children: implications for global challenges.
Sue Fairweather-Tait. Copper homeostasis: how stable isotope applications inform understanding

17:00 -17:30Coffee break
17:30 - 19:00 Posters session with cheese & beer
20:00Dinner & social activity
Tuesday, November 11, 2008
7:00 - 8:30 Breakfast
8:30 - 9:00

Plenary session. Leone Memorial Lectureship.
Carmen Donangelo. Zinc utilization in women during reproduction: evidence of physiologic adaptation.

9:00 – 10:30

Symposium 4. Selenoprotein P metabolism and functions in animals and humans
John Arthur (chair). Selenoprotein P: variations in response to selenium supplementation
Ray Burk. Selenoprotein P and "selenium status"
Lutz Schomburg. Selenoprotein P and disease in humans and animals.

9:00–10:30

Oral abstracts presentation session 1. Copper, zinc, and iron basic aspects.
Mauricio González (chair)

9:00–9:15 OR01 . The zinc transporter 3 (ZnT3) sorting and transport activity are regulated by covalent ZnT3-oligomers. Gloria Salazar and Victor Faundez.
9:15-9:30 OR02. Dietary iron affects proteins involved in iron metabolism in weanling pigs. Stephanie L Hansen and Jerry W Spears.
9:30-9:45 OR03. Effect of zinc on hepatic copper and iron concentrations in experimentally induced copper toxicity in rats. Carmen Fuentealba, Susan Haywood, Kent G. Hecker and Jim Trafford
9:45-10:00 OR04. Live imaging of metal-ion transport in oocytes expressing the human divalent metal-ion transporter DMT1: substrate profile and selectivity of DMT1. Anthony C Illing, Ali Shawki, Christopher L Cunningham, and Bryan Mackenzie
10:00-10:15 OR05. Dual-localization of ZnT2 to mitochondria and exocytotic vesicles redistributes zinc pools in mammary cells. Young Ah Seo, Veronica Lopez and Shannon L Kelleher
10:15-10:30 OR06. Is copper chaperone for cu/zn superoxide dismutase a potential biomarker of mild copper supplementation? Mir iam Suazo, Talía del Pozo, Marco Méndez, Mauricio González and Magdalena Araya .
9:00–10:30

Oral abstracts presentation session 2. Health hazards
Mary L'Abbé (chair)

9:00–9:15 OR07. Long term effects of cadmium on forearm bone density in a chinese population. Xiao Chen, Guoying Zhu, Taiyi Jin, Agneta Åkesson , Ingvar A. Bergdahl , Lijian Lei, Shifang Weng and Yihuai Liang
9:15-9:30 OR08. Glutathione modulation influences methyl mercury induced toxicity in albino rats. Varsha Singh, Deepmala Joshi, Sadhana Shrivastava, Sangeeta Shukla and Mohammed Abdullah
9:30-9:45 OR09. Effects of complex I inhibition on mitochondrial iron homeostasis, in an experimental model of parkinson's disease. Natalia Mena, Julio Salazar, Enrique Armijo, H. Stephen, Etienne Hirsch and Marco Tulio Núñez.
9:45-10:00 OR10. Competition between oligomeric silicic acid and transferrin for aluminium binding and implications for aluminium toxicity. Sylvaine FA Bruggraber, Ravin Jugdaohsingh, William Cook and Jonathan J. Powell
10:00-10:15 OR11. Comparison of prenatal biomarkers of low-level methyl mercury exposure. Janja Tratnik, Irena Rupnik and Milena Horvat
10:15-10:30 OR12. Rapid screening of toxic elements via X-ray fluorescence spectrometry. Richard Jacobs, Janet McDonald and Peter Palmer.
10:30-11:00 Coffee break
11:00-13:00

Symposium 5. Trace elements and the central nervous system
Joe Prohaska (chair). Impact of copper deficiency on brain energy metabolism
Raymond Burk. Selenoprotein P and brain function
John Beard. Iron deficiency and neural functioning

Symposium 6. New approaches to define TE biomarkers
Magdalena Araya (co-chair)
Harry McArdle (co-chair). Identification of biomarkers for micronutrient status – a comparison of genomics and proteomics approaches.
Ioav Z Cabantchik. Misdistribution of iron: causes, pathological implications and attempts of correction. Ruan Elliott. What is the true potential of transcriptomic methods for biomarker discovery in trace element research?
John Beattie. Zinc biomarker discovery: light at the end of the tunnel?

Symposium 7. Interventions with trace elements in susceptible populations
Manuel Ruz (chair)
Rosalind Gibson. Interventions for combating micronutrient deficiencies in Africa : problems, progress, and future solutions.
Emorn Wasantwisut. Trace elements interventions in Asia : knowledge vs challenges
Daniel Lopez de Romaña. Recent trace elements interventions in Latin America
Noel Solomons. Interventions with trace elements (TES) in susceptible populations: when does safety trump efficacy?
13:00 - 14:00 Lunch
15:00 Social activity. Trip to “Termas del Huife”
Wednesday, November 12, 2008
7:00 - 8:30Breakfast
8:30 - 9:00

Plenary session. Underwood Lecture.
Janet King. Why are indicators of zinc status so elusive?

9:00 – 10:30

Oral abstracts presentation session 3. Trace elements in animal metabolism
Fernando Wittver (chair)

9:00–9:15 OR13. Effect of selenium supplementation on somatic cell counts in grazing dairy cattle. Alejandro Ceballos , Juan Kruze, Daniel Uribe, Javier Sanchez, Ian Dohoo, Herman Barkema, Jeff Wichtel, Javier Neumann and Fernando Wittwer.
9:15-9:30 OR14. Persistence of blood changes associated with alteration of the dietary electrolyte balance following feed withdrawal, transportation and lairage in market weight swine . Lily N. Edwards, Terry E. Engle, Temple Grandina and David B. Anderson.
9:30-9:45 OR15. Effects of copper on ruminal fermentation and biohydrogenation of unsaturated fatty acids in vitro . Jennifer S. Schutz and Terry E. Engle.
9:45-10:00 OR16. Dietary silicon: a beneficial mediator of immunoregulating and stress proteins in mammals? Sarah Ratcliffe, Ravin Jugdaohsingh and Jonathan J Powell
10:00-10:15 OR17. Effects of long-term copper deficiency on gene expression profiles of copper transporters and chaperones in the liver of cattle. Robert S. Fry, Melissa S. Ashwell, Stephanie L. Hansen, Terry E. Engle, Hyungchul Han and Jerry W. Spears
10:15-10:30 OR18. Effect of dietary antagonists on copper metabolism of sheep. Alexander M. Mackenzie, Carolyn M. Atkin, Nia Griffith, Claire L. Williams, Simon G. Edwards and Robert G. Wilkinson

9:00 – 10:30

Oral abstracts presentation session 4. Iodine and selenium
Sean Stain (chair)

9:00–9:15 OR19. The effect of high iodine intake on thyroid hormones and selenium status in older people. Christine Thomson, Jenny Campbell, Jody Miller and Sheila Skeaff
9:15-9:30 OR20. Probiotics and selenium metabolism: does it matter whether the bacteria are dead or alive? Woravimol Krittaphol, Philip Wescombe, Arlene McDowell, John R. Tagg, Christine D. Thomson and J. Paul Fawcett
9:30-9:45 OR21. Iodine status and cognitive function of women of childbearing age and their five year-old children in Sidama, Southern Ethiopia . Alemtsehay Bogale, Cherinet Abuye, Kassu Gurmu, Yewelsew Abebe, K Michael Hambidge and Barbara J Stoecker
9:45-10:00 OR22. Selenium in milk – selenium speciation and health effects. Tien Hoac, Peter Olsson, Vasileios Pagmantidis, Gitte Ravn-Haren, Jan Stagsted, Susanne Bügel, Gunilla Önning, Jacob H. Nielsen, Lars O. Dragsted and Björn Åkesson
10:00-10:15 OR23. Selenium and human cancer. From epidemiological data to molecular biology study. Wojciech Wasowicz, Ewa Jablonska, Edyta Reszka and Jolanta Gromadzinska
10:15-10:30 OR24. Selenoprotein W MRNa expression analysis in human colonic mucosa using affymetrix HGU133 plus 2.0 microarrays and real-time PCR. Jeannette Molnár, Orsolya Galamb, Ferenc Sipos, Sándor Spisák, Kinga Tóth, Norbert Solymosi, Annamária Németh, Zsolt Tulassay, Béla Molnár

9:00 – 10:30

Oral abstracts presentation session 5. Iron and zinc metabolism and interventions.
Shannon Kelleher (chair)

9:00–9:15 OR25. One-day zinc kinetics, a versatile tool for analysis of human zinc metabolism and its application. Katsuhiko Yokoi, Harold H. Sandstead, Norman G. Egger, Nancy W. Alcock, V.M. Sadagopa Ramanujam, Hari H. Dayal and James G. Penland
9:15-9:30 OR26. Hepcidin and its role in regulating intestinal iron transport. Paul Sharp, Bomee Chung, Timothy Chaston, Joanne Marks, Edward Debnam and Surjit Srai
9:30-9:45 OR27. Intakes and impact of dietary factors affecting iron availability in the Medical Research Council National Survey of Health and Development (MRC NSHD) (1946 British birth cohort) between 1982 and 1999. Anna P. Rickard, Mark D. Chatfield, Jonathan J. Powell and Alison M. Stephen
9:45-10:00 OR28. Short-term inhibitory effect of calcium on iron absorption persists after an extended course of calcium supplementation in young women with limited iron stores. Karima Benkhedda, Mary R. L'Abbé and Kevin A. Cockell
10:00-10:15 OR29. Maternal dietary zinc supplementation prevents cognitive impairment in adult offspring of mice exposed to infection (LPS) in early pregnancy. Allan M Rofe, Nancy Tran, Jenny N.T. Fung, Brooke L Summers, Joanne S Chua and Peter Coyle
10:15-10:30 OR30. Zinc and iron absorption and nutritional status is reduced after gastric bypass in morbidly obese patients. Manuel Ruz , Fernando Carrasco, Pamela Rojas, Attila Csendes, Karin Papapietro, Jorge Inostroza, Annabella Rebolledo, Karen Basfifer, Fernando Pizarro, Manuel Olivares, Nancy Krebs, Jamie Westcott, Michael Hambidge.
10:30-11:00 Coffee break
11:00-13:00

Simposium 8. Trace elements in neurodegeneration.
Tulio Nuñez (chair)
George Perry. Evidence of increased copper and iron but not zinc in Alzheimer's disease: energy dispersive X-ray spectroscopy (EDS) elemental microanalysis.
Carlos Opazo. Untuning of protein-metal interactions in Alzheimer disease.
Etienne Hirsch. Iron in Parkinson's disease.
Moussa Youdim. Multifunctional iron chelators neuroprotective and neurorestorative drugs for alzheimer's disease.

Symposium 9. Trace elements and vascular disease
Y. James Kang (chair). Copper metabolic disorder in heart failure
John Beattie. Zinc in vascular health and disease
Markus Brielmeier. The morphological and functional integrity of cardiomyocytes critically depends on the selenoprotein mitochondrial thioredoxin reductase.
Huiqi Xie. Copper and zinc metabolic changes and manipulation in hypertension.

Symposium 10. Animal nutrition current problems
Xin Gen Lei (chair)
Dennis Miller. Prebiotics and iron bioavailability: Using the piglet as a model to study effects and mechanisms.
Jerry Spears. Trace mineral transporters: implications for animal nutrition.
Zongyong Jiang. Potential of supplemental selenium in improving meat quality of food animals.

13:00-14:00 Lunch
15:00-17:00

Symposium 11. Trace elements interactions in health.
Bo Lönnerdal (chair). Iron-Zinc Interactions: effect of maternal Fe and Zn supplementation on offspring Fe and Zn homeostasis.
James Collins. The Menkes copper ATPase (ATP7A) is novel iron responsive gene in the mammalian intestine.
Richard Hurrell. Contradictory findings on the influence of vitamin A on iron bioavailability in human subjects.
Ralf Biebinger. Interactions of vitamin a and iodine deficiencies: effects on the pituitary TSHB-gene and the thyroid axis.

Symposium 12. Increasing awareness on selected trace elements
Michael Garrick (chair). Increasing awareness of selected trace elements.
Jerry Roth. Role of NF-?B and parkin in regulating DMT1 expression and manganese toxicity.
Laura Garrick. Accumulation of trace metals as an assay for transport (by DMT1)
Brian Mackenzie. Substrate profile and selectivity of the human divalent metal-ion transporter DMT1.

Symposium 13. Trace element transport and its regulation
Jim Camakaris (chair). The pivotal role of the Menkes copper ATPase in copper transport and regulation of its function
José Arguello. Ferrying Cu across the membrane: molecular mechanism of Cu-ATPases.
Miguel Arredondo. New insights in heme and none-heme iron transport
Robert Cousins. Zinc transport and signaling

17:00-17:30 Coffee break
17:30-19:00 Posters session with cheese & beer
20:00 Dinner & social activity
Thursday, November 13, 2008
7:00 - 9:00 Breakfast
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